Autologous hematopoietic stem cell transplantation in the treatment of systemic sclerosis. Part 2. Safety and complications
نویسندگان
چکیده
Autologous hematopoietic stem cell transplantation (auto-HSCT) is presently the only disease-modifying strategy for treatment of systemic sclerosis (SSs) that has Level A evidence, effectiveness which been proven in three controlled clinical trials: ASSIST, ASTIS, and SCOT. Despite positive results obtained with use this option, issues related to its tolerability safety remain unresolved. The complications caused by obvious immunosuppression higher frequency infections are main causes death after autoHSCT autoimmune diseases occur mainly first month treatment. Overall, studies performed confirm overall assessment auto-HSCT as an effective relatively safe severe SSs.
منابع مشابه
High-Dose Immunosuppressive Therapy and Autologous Hematopoietic Stem Cell Transplantation for Treatment of Severe Systemic Sclerosis
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Oral Ciprofloxacin Prophylaxis in Patients Undergoing High Dose Therapy and Autologous Hematopoietic Stem Cell Transplantation
Background: Antibiotic prophylaxis is usually used in allogenic stem cell transplantation, but its use in Autologous Stem Cell Transplantation (ASCT) is controversial. We evaluated the efficacy of ciprofloxacin prophylaxis in ASCT. Materials and Methods: To identify the efficacy of ciprofloxacin on the incidence of neutropenic fever and its complications, 72 patients had been admitted to Talegh...
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متن کاملAutologous stem cell transplantation in systemic sclerosis: a systematic review.
OBJECTIVES Haematopoetic autologous stem cell transplantation (ASCT) has emerged as a treatment option for patients with refractory, severe autoimmune disease. This is a systematic review of the current literature on ASCT in adult patients with systemic sclerosis (SSc). METHODS Original articles published between 2005 and 2016 that evaluated the use of ASCT in patients with SSc were reviewed ...
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ژورنال
عنوان ژورنال: Sovremennaâ Revmatologiâ
سال: 2021
ISSN: ['2310-158X', '1996-7012']
DOI: https://doi.org/10.14412/1996-7012-2021-1-66-72